Mapping Rare and Common Causal Alleles for Complex Human Diseases

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Mapping Rare and Common Causal Alleles for Complex Human Diseases

Advances in genotyping and sequencing technologies have revolutionized the genetics of complex disease by locating rare and common variants that influence an individual's risk for diseases, such as diabetes, cancers, and psychiatric disorders. However, to capitalize on these data for prevention and therapies requires the identification of causal alleles and a mechanistic understanding for how t...

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ژورنال

عنوان ژورنال: Cell

سال: 2011

ISSN: 0092-8674

DOI: 10.1016/j.cell.2011.09.011